A comprehensive, contemporary assessment of the association between hepatosteatosis and coronary artery calcium scoring

Abstract Funding Acknowledgements Type of funding sources: None. onbehalf Liverpool Multiparametric Imaging Collaboration Background Coronary artery calcium (CAC) score is a well-established technique for stratifying an individual’s cardiovascular disease (CVD) risk. Several registries have incorporated CAC scoring into CVD risk prediction models to enhance accuracy. Hepatosteatosis (HS) has been shown be independent predictor events and can measured on non-contrast computed tomography (CT). We sought undertake contemporary, comprehensive assessment the influence HS alongside traditional factors. In patients with it may beneficial offer routine screening evaluate opportunities earlier primary prevention strategies. Methods performed retrospective, observational analysis at high-volume cardiac CT centre analysing consecutive coronary angiography (CTCA) studies. All referred investigation chest pain over 28-month period (June 2014 November 2016) were included. Patients established excluded. The findings reported by cardiologist retrospectively analysed two radiologists presence HS. Those zero those greater than compared demographic risks. A multivariate comparing factors was adjust binomial logistic regression model developed assess association between increasing strata CAC. Results total there 1499 CTCA without prior evidence CVD. completed in 1195 (79.7%) 1103 (92.3%). There 466 637 prevalence significantly higher versus (51.3% 39.9%, p = 0.007). Male sex (50.7% 36.1% p= <0.001), age (59.4 ± 13.7 48.1 13.6, <0.001) diabetes (12.4% 6.9%, 0.04) also group zero. associated (CAC 1-100 OR1.47, 0.01, 101-400 OR:1.68, 0.02, >400 OR 1.42, 0.14). This became non-significant highest score. Conclusion found significant age, male sex, more severe phenotype based multinomial model. Although reduced >400) this likely reflects overall low numbers within type II error. Based these appropriate stratification techniques all diagnosed